The medical virtues of cannabis:
still waiting for evidence
As you browse websites that sell cannabis products, you'll likely read that this drug relieves chronic pain, arthritis, and many other conditions. But don't expect to find clinical evidence to support this claim.
Stephanie Keeling is a rheumatologist and professor of medicine at the University of Alberta. She currently participates in the Certificate in Health Impact program at the Dalla Lana School of Public Health at the University of Toronto.
Four years after cannabis was legalized, the federal government's clinical trials database at Health Canada does not demonstrate strong active research to evaluate its purported medicinal properties. This gap frustrates many researchers, who say that cannabis growers, processors and sellers in Canada have little incentive to fund rigorous pharmaceutical analyses of their claims.
According to the researchers, the industry is content to sell its products in compliance with
the less stringent requirements that govern the recreational consumption market.
"Cannabis producers are unwilling to support medical access," says Mary-Ann Fitzcharles, an associate professor of medicine at McGill University and a leading pain researcher. She adds that early hopes of a partnership between industry
and researchers to conduct the necessary studies have vanished.
This lack of data does not allow patients trying to relieve their ailments — or their doctors — to verify the accuracy of claims by cannabis-related companies and some patient advocacy groups. The studies cited by these companies to support their claims are not clinical trials, they are mainly patient surveys and observational studies often conducted by the companies themselves, which can lead to considerable bias. Approximately 400,000 Canadians currently have a medical cannabis licence issued by their doctor,
and it is believed that many others are using it in the same way.
But there is no data yet on its effectiveness or potential harm.
The scientific community attributes this failure to various reasons. The legalization of cannabis in Canada in 2018 opened the door to collaborations between researchers and industry to finally test its medicinal properties using the reference standard: clinical trials. However, cannabis is classified as a drug under the Food and Drugs Act, so it must comply with Health Canada's good manufacturing practices to consistently meet quality standards. For companies in the sector, this research process is more complicated and costly than the less difficult process of obtaining authorization to market cannabis for recreational purposes. Even if a researcher wanted to legally purchase cannabis from a local supplier and test it, they would have to go back to the starting point and conduct many more studies to successfully file a clinical trial application with Health Canada for this form of cannabis.
The researchers also point out that studies can be hampered by the complexity of the ingredients that make up cannabis products, including the highly variable amounts of tetrahydrocannabinol (THC), the chemical that makes you get high.
But they also criticize Health Canada for not proactively streamlining the cannabis clinical trial process while ensuring quality standards. Last year, more than 200 clinicians and scientists wrote an open letter to Health Canada calling for a review of the current regulatory process.
So far, little has changed on this front. A few tweaks have made it easier for a handful of researchers to obtain research licenses and permission to start conducting cannabis studies in certain situations, such as when there is adequate safety data for humans.
This, however, is not enough to prioritize the cannabis studies that researchers say they need, as most cannabis product candidates still need to be thoroughly studied preclinically and safely.
"A separate pathway for prescription cannabis products is not being considered at this time," said Tammy Jarbeau, Senior Media Relations Advisor for Health Canada. A mandatory review of the Cannabis Act, which was scheduled to begin in October 2021, is expected shortly, according to Jarbeau. It is unclear whether this review will focus on ways to improve Health Canada's regulation of cannabis studies.
Four years after cannabis was legalized, the federal government's clinical trials database at Health Canada does not demonstrate strong active research to evaluate its purported medicinal properties. This gap frustrates many researchers, who say that cannabis growers, processors and sellers in Canada have little incentive to fund rigorous pharmaceutical analyses of their claims.
According to the researchers, the industry is content to sell its products in compliance with
the less stringent requirements that govern the recreational consumption market.
"Cannabis producers are unwilling to support medical access," says Mary-Ann Fitzcharles, an associate professor of medicine at McGill University and a leading pain researcher. She adds that early hopes of a partnership between industry
and researchers to conduct the necessary studies have vanished.
This lack of data does not allow patients trying to relieve their ailments — or their doctors — to verify the accuracy of claims by cannabis-related companies and some patient advocacy groups. The studies cited by these companies to support their claims are not clinical trials, they are mainly patient surveys and observational studies often conducted by the companies themselves, which can lead to considerable bias. Approximately 400,000 Canadians currently have a medical cannabis licence issued by their doctor,
and it is believed that many others are using it in the same way.
But there is no data yet on its effectiveness or potential harm.
The scientific community attributes this failure to various reasons. The legalization of cannabis in Canada in 2018 opened the door to collaborations between researchers and industry to finally test its medicinal properties using the reference standard: clinical trials. However, cannabis is classified as a drug under the Food and Drugs Act, so it must comply with Health Canada's good manufacturing practices to consistently meet quality standards. For companies in the sector, this research process is more complicated and costly than the less difficult process of obtaining authorization to market cannabis for recreational purposes. Even if a researcher wanted to legally purchase cannabis from a local supplier and test it, they would have to go back to the starting point and conduct many more studies to successfully file a clinical trial application with Health Canada for this form of cannabis.
The researchers also point out that studies can be hampered by the complexity of the ingredients that make up cannabis products, including the highly variable amounts of tetrahydrocannabinol (THC), the chemical that makes you get high.
But they also criticize Health Canada for not proactively streamlining the cannabis clinical trial process while ensuring quality standards. Last year, more than 200 clinicians and scientists wrote an open letter to Health Canada calling for a review of the current regulatory process.
So far, little has changed on this front. A few tweaks have made it easier for a handful of researchers to obtain research licenses and permission to start conducting cannabis studies in certain situations, such as when there is adequate safety data for humans.
This, however, is not enough to prioritize the cannabis studies that researchers say they need, as most cannabis product candidates still need to be thoroughly studied preclinically and safely.
"A separate pathway for prescription cannabis products is not being considered at this time," said Tammy Jarbeau, Senior Media Relations Advisor for Health Canada. A mandatory review of the Cannabis Act, which was scheduled to begin in October 2021, is expected shortly, according to Jarbeau. It is unclear whether this review will focus on ways to improve Health Canada's regulation of cannabis studies.
The government's slow response is disheartening, says James MacKillop, professor of psychiatry and behavioral neuroscience and director of the Michael G. DeGroote Center for Medical Cannabis Research at McMaster University. "I would have liked to have seen an evaluation of the therapeutic virtues of products legally sold to Canadians," says MacKillop. "Why not create a pathway
to assess whether the products Canadians consume are effective or not?"
Cannabis-related businesses share the frustration with the way studies are conducted in Canada. Some of them, such as Canopy Growth Corporation, located in Ontario, claim to be doing trials in other countries, including, in recent years, the United States, where federal laws such as the Farm Bill make it easier for academic institutions to conduct studies on the health effects of cannabis.
But the industry recognizes that strong financial headwinds in the cannabis sector, which have pushed some companies to close down and others merge to survive, have diverted attention and resources from clinical research, slowing the buildup of solid evidence.
"Companies like Canopy need to set their priorities — where to invest their money and where to put their energy," says Mark Ware, chief medical officer at Canopy Growth Corporation. Like other companies in the sector in Canada, he says, Canopy has focused more on the commercial side than on medical research. "At the time we were dealing with these issues, the company did some reorganizations and redefined its strategies; the idea of further development of pharmaceuticals was not a priority at that time," says Mark Ware.
Patients, on the other hand, cannot expect clear answers from their rights organizations. Cannabis information on the Arthritis Society's website is sponsored by companies like Spectrum Therapeutics, a pharmaceutical company owned by Canopy Growth. Spectrum Therapeutics' website states that it provides "cannabis-based medical products to improve the lives of patients around the world."
The Arthritis Society's website devotes several pages to the medical use of cannabis for pain control, with information on everything from how to access online webinars hosted by doctors — and sponsored by cannabis producers such as Harvest Medicine and Canna Farms.
Siân Bevan, executive director of science at the Arthritis Society, is not insensitive to the lack of evidence. She points out that the Arthritis Society is funding cannabis research to fill this void, but in the meantime, it needs to help the many Canadians who are already using cannabis to relieve their pain. "People want to understand what we know and what we don't know, and we can provide this platform for people who come to us for information," says Siân Bevan.
The researchers insist that only evidence from clinical trials can remove this uncertainty. "It seems to me that we should do everything we can to assess the pros and cons [of medical cannabis use]," says MacKillop.
to assess whether the products Canadians consume are effective or not?"
Cannabis-related businesses share the frustration with the way studies are conducted in Canada. Some of them, such as Canopy Growth Corporation, located in Ontario, claim to be doing trials in other countries, including, in recent years, the United States, where federal laws such as the Farm Bill make it easier for academic institutions to conduct studies on the health effects of cannabis.
But the industry recognizes that strong financial headwinds in the cannabis sector, which have pushed some companies to close down and others merge to survive, have diverted attention and resources from clinical research, slowing the buildup of solid evidence.
"Companies like Canopy need to set their priorities — where to invest their money and where to put their energy," says Mark Ware, chief medical officer at Canopy Growth Corporation. Like other companies in the sector in Canada, he says, Canopy has focused more on the commercial side than on medical research. "At the time we were dealing with these issues, the company did some reorganizations and redefined its strategies; the idea of further development of pharmaceuticals was not a priority at that time," says Mark Ware.
Patients, on the other hand, cannot expect clear answers from their rights organizations. Cannabis information on the Arthritis Society's website is sponsored by companies like Spectrum Therapeutics, a pharmaceutical company owned by Canopy Growth. Spectrum Therapeutics' website states that it provides "cannabis-based medical products to improve the lives of patients around the world."
The Arthritis Society's website devotes several pages to the medical use of cannabis for pain control, with information on everything from how to access online webinars hosted by doctors — and sponsored by cannabis producers such as Harvest Medicine and Canna Farms.
Siân Bevan, executive director of science at the Arthritis Society, is not insensitive to the lack of evidence. She points out that the Arthritis Society is funding cannabis research to fill this void, but in the meantime, it needs to help the many Canadians who are already using cannabis to relieve their pain. "People want to understand what we know and what we don't know, and we can provide this platform for people who come to us for information," says Siân Bevan.
The researchers insist that only evidence from clinical trials can remove this uncertainty. "It seems to me that we should do everything we can to assess the pros and cons [of medical cannabis use]," says MacKillop.
Stephanie Keeling
Actualité
The medical virtues of cannabis: still waiting for evidence | Current events (lactualite.com)
Actualité
The medical virtues of cannabis: still waiting for evidence | Current events (lactualite.com)
